Peer Reviewed Research Publications and Reviews

#joint first authorships, *joint corresponding authorships.

41. Xie J, de Souza Alves V, von der Haar T, O'Keefe L, Lenchine RV, Jensen KB, Liu R, Coldwell MJ, Wang X, Proud CG (2019) Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan. Current Biology, 29: xx-yy.

40. Jossé L, Singh T, von der Haar T (2019) Experimental determination of codon usage-dependent selective pressure on high copy-number genes in Saccharomyces cerevisiae. Yeast, 36: 43-51.

39. Khan MF, Spurgeon SK, von der Haar T (2018) Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2. Journal of Theoretical Biology, 445: 92-102.

38. Bastide A, Peretti D, Knight JRP, Grosso S, Spriggs RV, Pichon X, Sbarrato T, Roobol A, Roobol J, Vito D, Bushell M, von der Haar T, Smales CM, Mallucci GR and Willis AE (2017) RTN3, a novel cold-induced protein, mediates the neuroprotective effects of RBM3. Curr Biol 27: 638-650.

37. Saintas E, Abrahams L, Ahmad GT, Ajakaiye AM, AlHumaidi AS, Ashmore-Harris C, Clark I, Dura UK, Fixmer CN, Ike-Morris C, Mato Prado M, Mccullough D, Mishra S, Schöler KM, Timur H, Williamson MD, Alatsatianos M, Bahsoun B, Blackburn E, Hogwood CE, Lithgow PE, Rowe M, Yiangou L, Rothweiler F, Cinatl J Jr, Zehner R, Baines AJ, Garrett MD, Gourlay CW, Griffin DK, Gullick WJ, Hargreaves E, Howard MJ, Lloyd DR, Rossman JS, Smales CM, Tsaousis AD, von der Haar T, Wass MN and Michaelis M (2017) Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS. PLoS One, 12: e0172140.

36. von der Haar T*, Leadsham JE, Sauvadet A, Tarrant DS, Adam IS, Saromi K, Laun P, Rinnerthaler M, Breitenbach-Koller H, Breitenbach M, Tuite MF and Gourlay CW * (2017) The control of translational accuracy is a determinant of healthy ageing in yeast. Open Biol, 7: 160291.

35. Tarrant DS, Stirpe M, Rowe M, Howard MJ, von der Haar T*, and Gourlay CW* (2016) Inappropriate expression of the translation elongation factor 1A disrupts genome stability and metabolism. J Cell Sci, 129:, 4455-4465.

34. Bill RM and von der Haar T (2015) Hijacked then lost in translation: the plight of the recombinant host cell in membrane protein structural biology projects. Curr Opin Struct Biol 32: 147-155.

33. Beznosková P, Wagner S, Jansen ME, von der Haar T and Valášek LS (2015) Translation initiation factor eIF3 promotes programmed stop codon readthrough. Nucleic Acids Res 43: 5099-5111.

32. Blanchet S, Rowe M, von der Haar T, Fabret C, Demais S, Howard M and Namy O (2015) New insights into stop codon recognition by eRF1. Nucleic Acids Res 43: 3298-3308.

31. Tarrant D and von der Haar T (2014) Synonymous codons, ribosome speed, and eukaryotic gene expression regulation. Cell Mol Life Sci 71: 4195-206.

30. Chu D, Thompson J and von der Haar T (2014) Charting the dynamics of translation. BioSystems 119: 1-9.

29. Chu D, Kazana E, Bellanger N, Singh T, Tuite MF and von der Haar T (2014) Translation elongation can control translation initiation on eukaryotic mRNAs. EMBO J 33: 21-34.

28. Beznosková P, Cuchalová L, Wagner S, Shoemaker CJ, Gunišová S, von der Haar T and Valášek LS (2013) Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells. PLoS Genet 9: e1003962.

27. Bauer JW, Brandl C, Haubenreisser O, Wimmer B, Weber M, Karl T, Klausegger A, Breitenbach M, Hintner H, von der Haar T, Tuite MF and Breitenbach-Koller L (2013) Specialized yeast ribosomes: a customized tool for selective mRNA translation. PLoS One 8: e67609.

26. Hopker JG, Coleman DA, Gregson HC, Jobson SA, von der Haar T, Wiles J and Passfield L (2013) The influence of training status, age, and muscle fiber type on cycling efficiency and endurance performance. J Appl Physiol 115: 723-729.

25. Mead EJ, Chiverton LM, Spurgeon SK, Martin EB, Montague G, Smales CM and von der Haar T (2012) Experimental and in silico modelling analyses of the gene expression pathway for recombinant antibody and by-product production in NS0 cell lines. PLoS One 7: e47422.

24. Chu D and von der Haar T (2012) The architecture of eukaryotic translation. Nucleic Acids Res 40: 10098-10106.

23. Jossé L, Marchante R, Zenthon J, von der Haar T and Tuite MF (2012) Probing the role of structural features of mouse PrP in yeast by expression as Sup35-PrP fusions. Prion 6: 201-210.

22. von der Haar T (2012) Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview. Comp Struct Biotech J 1: e201204002.

21. Chu D, Zabet N and von der Haar T (2012) A novel and versatile computational tool to model translation. Bioinformatics 28: 292-293.

20. Chu D, Barnes DJ and von der Haar T (2011) The role of tRNA and ribosome competition in coupling the expression of different mRNAs in Saccharomyces cerevisiae. Nucleic Acids Res 39: 6705-6714.

19. Merritt GH, Naemi WR, Mugnier P, Webb HM, Tuite MF and von der Haar T (2010). Decoding accuracy in eRF1 mutants and its correlation with pleiotropic quantitative traits in yeast. Nucleic Acids Res 38: 5479-5492.

18. Mead EJ, Chiverton LM, Smales CM and von der Haar T (2009). Identification of the limitations on recombinant gene expression in CHO cell lines with varying luciferase production rates. Biotech Bioeng 102: 1593-1602.

17. von der Haar T (2008). A quantitative estimation of the global translational activity in logarithmically growing yeast cells. BMC Syst Biol 2: 87.

16. Studte P, Zink S, Jablonowski D, Bär C, von der Haar T, Tuite MF and Schaffrath R(2008). tRNA and protein methylase complexes mediate zymocin toxicity in yeast. Mol Microbiol 69: 1266-1277.

15. von der Haar T (2007). Optimized protein extraction for quantitative proteomics of yeasts. PLoS One 2: e1078.

14. McCarthy JEG, Marsden S and von der Haar T (2007). Biophysical studies of the translation initiation pathway using immobilised mRNA analogues. Methods Enzymol 430: 247-264.

13. von der Haar T, Jossé L, Wright P, Zenthon J and Tuite MF (2007). Development of a novel yeast cell-based system for studying the aggregation of Alzheimer’s Disease-associated Aβ peptides in vivo. Neurodegener Dis 4: 136-147.

12. Gilbert RJC, Gordiyenko Y, von der Haar T, Sonnen AFP, Hoffmann G, Nardelli M, Stuart DI and McCarthy JEG (2007). Reconfiguration of yeast 40S ribosomal subunit domains by the translation initiation multifactor complex. Proc Natl Acad Sci USA 104 14: 5788-5793.

11. von der Haar T and Tuite MF (2007). Regulated translational by-pass of stop codons in yeast. Trends Microbiol 15: 78-86.

10. von der Haar T, Oku Y, Ptushkina M, Moerke N, Wagner G, Gross JD and McCarthy JEG (2006). Folding transitions during assembly of the eukaryotic mRNA cap-binding complex. J Mol Biol 356: 982-992.

9. von der Haar T, Gross JD, Wagner G and McCarthy JEG (2004). The mRNA cap-binding protein in post-transcriptional gene expression. Nat Struct Mol Biol 11: 503-511.

8. Gross JD, Moerke NJ, von der Haar T, Lugovskoy AA, Sachs AB, McCarthy JEG and Wagner G (2003). Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell 115: 739-750.

7. #He H, #von der Haar T, #Singh CR, Ii M, Li B, Hinnebusch AG, McCarthy JEG and Asano K (2003). The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection. Mol Cell Biol 23: 5431-5445.

6. von der Haar T and McCarthy JEG (2002). Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function. Mol Microbiol 46: 531-544.

5. Ptushkina M, Berthelot K, von der Haar T, Geffers L, Warwicker J and McCarthy JEG (2001). A second eIF4E protein in Schizosaccharomyces pombe has distinct eIF4G-binding properties. Nucleic Acids Res 29: 4561-4569.

4. von der Haar T, Ball PD and McCarthy JEG (2000). Stabilization of eukaryotic initiation factor 4E binding to the mRNA 5 '-cap by domains of eIF4G. J Biol Chem 275: 30551-30555.

3. Ptushkina M, von der Haar T, Karim MM, Hughes JMX, McCarthy JEG (1999). Repressor binding to a dorsal regulatory site traps human elF4E in a high cap-affinity state. EMBO J 18: 4068-4075.

2. Hughes JMX, Ptushkina M, Karim MM, Koloteva N, von der Haar T, McCarthy JEG (1999). Translational repression by human 4E-BP1 in yeast specifically requires human eIF4E as target. J Biol Chem 274: 3261-3264.

1. #Ptushkina M, #von der Haar T, Vasilescu S, Frank R, Birkenhäger R, McCarthy JEG (1998). Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5 ' cap in yeast involves a site partially shared by p20. EMBO J 17: 4798-4808.

Other Publications

7. Sesma A and von der Haar T (editors) (1014) Fungal RNA Biology. 408 pp, Springer, Heidelberg, ISBN 978-3-319-05687-6.

6. Mead EJ, Masterton RJ, von der Haar T, Tuite MF and Smales CM (2014) Control and regulation of mRNA translation. Biochem Soc Trans 42 : 151-154.

5. Kazana E and von der Haar T (2014) The translational machinery is an optimized molecular network that affects cellular homoeostasis and disease. Biochem Soc Trans 42 : 173-176.

4. von der Haar T (2009) One for all ? A viral protein supplants the mRNA cap-binding complex. EMBO J., 28(1), 6-7. (Invited comment on : Mir, MA and Panganiban, AT (2008). A protein that replaces the entire cellular eIF4F complex. EMBO J. 27(23), 3129-39.)

3. von der Haar T, Jossé LJ and Byrne LJ (2007). Reporter genes and their uses in studying yeast gene expression. In Methods Microbiol., 36 (Yeast Gene Analysis 2nd edition), Stansfield I and Stark MJ (eds.), Academic Press Inc., pp. 165-188.

2. von der Haar T and McCarthy JEG (2003). Studying the assembly of multicomponent protein and ribonucleoprotein complexes using surface plasmon resonance. Methods 29 (2), 167-174.

1. von der Haar T, Hughes JMX, Karim MM, Ptushkina M, McCarthy JEG (2002). Translation initiation and surface plasmon resonance: new technology applied to old questions. Biochem. Soc. Trans. 30, 155-162.